Keep track of Closely (1)oxcarbazepine will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to your reduce in fentanyl plasma concentrations, insufficient efficacy or, maybe, enhancement of the withdrawal sy
buprenorphine subdermal implant and fentanyl equally enhance sedation. Avoid or Use Alternate Drug. Limit use to patients for whom option treatment options are insufficientCheck Closely (two)primidone will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration
Often evaluate patients, particularly when initiating and titrating dose and when given concomitantly with other drugs that depress respiration; alternatively, consider use of non-opioid analgesics in these patientsIf coadministration of CYP3A4 inhibitors with fentanyl is necessary, watch patients for respiratory depression and sedation at Regular